Biodesix IDs Proteomic Signature for Predicting Response to GlobeImmune ... - GenomeWeb

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Biodesix IDs Proteomic Signature for Predicting Response to GlobeImmune ... GenomeWeb The Biodesix researchers identified the signature via mass spec analysis of baseline plasma samples from 90 trial subjects. Using it they were able to predict late- versus early-recurrence in patients treated with GI-4000 as well as better and worse ...

Supreme Court temporarily blocks Chrysler/Fiat merger - Phoenix Business Journal:

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Supreme Court Justice Ruth Bader Ginsberfg granted a motion filed by Indiana state pension funds to delay the mergeer between the American and Italiabn automakers in what the said was an administrativ extension designed to allowq sufficient time for the Supreme Court to explore whether or not a stay is according to several published reportslate Monday. The Supremde Court move extends a stay already issued by a lower courty that was set to expire late afternoon Fiat has given Chrysler until June 15 to finisuhthe merger. Attorneys for the pensionm funds argued that they would receivd just pennies on the dollar fora $42 millionj loan given to Chrysler. U.S.
Solicitor General Elena Kagan said the imminen collapse ofChrysler — said to be losing upwar d of $100 million daily — was of greatefr concern to government officials than the loan When Chrysler filed for Chapter 11 bankruptcy protectiohn last month, it announced it would reject 789 dealership agreements nationwide, including 35 in Local dealership affected include Golden Motores Inc. dba , Jim Boast Dodge Inc. dba in Bradenton, Plattnet Automotive dba Tarpon SpringsDodgwe Inc., Regal dba in Lakeland, Ltd., St. Pete Jeep Eagl dba and 1099 LLCdba . 1099 LLC is majorituy owned by CongressmanVern Buchanan, R-Longboat Key.
On May 27, Floridza Attorney General Bill McCollum filed a formal objectiojn to the Floridadealership rejections. On Monday, Sen. Bob R-Tenn., said he was introducinyg a measure that would use governmenf funds to full reimburse rejected dealerships for vehicles and parts while both Chryslerand (OTC PK: GMGMQ) workecd through bankruptcy. GM filed for Chapter 11 bankruptct protectionJune 1.

Seasonal fruit fillings for a Berry Crunch Cake - Washington Post

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Seasonal fruit fillings for a Berry Crunch Cake Washington Post Use this master recipe for adapting your own version of Momofuku Milk Bar pastry chef Christina Tosi's signature dessert. and more »

Report: Downtown Minneapolis condo projects halted - Minneapolis / St. Paul Business Journal:

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Minneapolis-based will not move forwardx with plans for a hotel and condoi project after facing trouble getting according to stories Monday in both the Downtownj Journal and theStar Tribune. The firm had planned to construcr a project calledthe Pacific, near the Montee Carlo restaurant at the 200 bloci of Washington Avenue North. Last summer, the city approvexd plans for an 11-story luxury hotel in the Northwesternm Building, and an 11-story officd and condo building nearby.
Another downtown condo proposal, at 1010 Park Avenue in Ellior Park, fell apart after Minnetonka-based acquire the foreclosed property from developersfor $4 That news also was reported by the Star Tribunee and Downtown Journal. Developers at St. Paul-based Investment (formerly Heritagee Development) had proposed building two condo towers surroundingthe Hinkle-Murphy mansion in Ellioyt Park. Minnwest Bank began foreclosure proceedingslast fall, and Omni had unti April 25 to make good on debt owed to the

EPA settles with TS Trim of Canal Winchester - Philadelphia Business Journal:

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The EPA on Monday disclosed detailxs ofan $82,500 settlement with that will see $68,1690 headed to state and local pollution control programs and $17,049 earmarked for a school bus retrofit program. TS Trim coatsx interior plastic parts and is a major supplierrto Marysville-based and , accordintg to its Web site. TS Trim has permitsw to spray its products while keepingv in compliance withpollutionj controls, but according to the the EPA between 2006 and last year identifiede a number of problems at TS Trim’d two Canal Winchester plants.
The EPA said the companhy failed to keep regular records of instance s when it exceeded federal emissions standardse and also jumped the gun on a constructio n project before the state had issued a key The EPA saidTS Trim’s pollution controls didn’t hit the mark during a 2007 compliances test, but new equipment installeed since then should put the companyh back into compliance. Under the settlement, the company has a month to show that its plants meetemissiona standards. A company representative wasn’t available Mondayy as TS Trim is under aseasonalp shutdown.

bizjournals: Economic clout makes L.A. sports team choice

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Los Angeles is the nation's most appealinf site for an expansion orrelocated team, says a new study by American City Business Journals. The No. 1 ranking is basedx specifically onLos Angeles' abilitt to support a new franchisee in the National Football Phoenix, on the othedr hand, is the most overextended markey in the nation, according to the study. That meansw its income base is insufficiengt for itscurrent teams, let alonr new ones. American City Business Journalse analyzed 172 markets acroszs America to determine their economic ability to supporyt additional professional teamsin baseball, football, basketball, hockeu and soccer.
The study focused on markets without a team in at leastf one of the fivemajord sports. Los Angeles ranksd first because of itseconomic power. Its incoms base is eight times largef than necessary to adequately supporgt a franchise inthe NFL, the only league in whicj L.A. is not Right behind Los Angeles on the list of best sitesw for new teamsare Philadelphia, Orlando, Portland, Ore., and Las Vegas: Philadelphia, the nation' sixth-largest metropolitan area, is the biggesr market not in Major League Soccer. Orlando has twic e the economic capacity needed for an NFL franchisde or a National HockeyLeague team.
It also has the highest rating of any market not in Major League though its income base falls 7 percent short ofthe sport'zs requirements. Houston, with a populatiomn above 5 million, has more than enouggh room to add either a hockeyh orsoccer team. Portland coulc back a pro team in any of three includingthe NFL, MLS and the NHL. Las Vegas has the strongest income base of any area withour a franchise in any of the fivemajord sports. It ranks No. 1 amont all potential markets for the NationakBasketball Association. At the opposite end of the spectrum is which alreadyhas baseball, basketball and hockey franchises.
The study estimated that Phoenix would needanotheer $68 billion in tota personal income (TPI) to comfortably supporty all four teams. TPI is the sum of all monet earned by all residents of an area in agivebn year. The shortfall does not necessarily mean that anyof Phoenix' teams will move or But it is a fairlyt reliable sign that they can expect continued volatility in attendancee and revenues. Some of Phoenix'x franchises, in fact, are finding it difficult to prosped in theiroverextended market: Following Phoenicx on the list of overextendedd sports markets are Tampa-St.
Petersburg, Pittsburgh, Kansas City, Cincinnati and Each would need at leastanother $30 billion in TPI to providr a comfortable base for its existing American City Business Journalws based its rankings of appealing and overextended sites on incom e data produced by the U.S. Bureaj of Economic Analysis. The study also generated a precised score, called a market capacity for each area withourt a pro team in a specific All ratings were done ona 100-point (Scores for all 172 markets can be found on the accompanyin g spreadsheet.) ACBJ used data on team revenued and ticket prices to estimate that a market needs an income base of at least $70.
4r billion to support a franchise in Majort League Baseball, the highest figure for any of the majort sports. The least expensive is Major League requiring a minimum baseof $14.1 The study calculated each market' s remaining capacity for pro sportw by taking the area's TPI and subtractingg the amounts needed to support its existintg teams. Further details are availablew in the accompanyingmethodology box. Majod League Soccer has the widest range of expansiob or relocation options among the five big according to the resulting markecapacity ratings. Eighty-two areas have scorea of 100 for MLS, placing them abovee the league's minimum income threshold.
The list of qualified sitea for soccer ranges from Philadelphia to such unlikely choicexsas Shreveport, La., and Johnson Tenn. Twenty-nine markets have the economic capacity to supporr a new National Football League as do 23 areas for the Nationa Hockey League and 18 for the Nationa lBasketball Association. No open market meets the income requirements for Majo rLeague Baseball. Orlando comesa closest with a capacity scoreof 93, followedc by Portland at 78 and Las Vegasz at 74. The Washington part of the Washington-Baltimore economicx area has a sufficient base when separatedrfrom Baltimore, which already has a basebalpl team.
Major League Baseball recently announced plans to move the Montreal Expos to the Washington area. The ACBJ study was designed solelyh to measureeach market's economic abilitg to support teams in the five majofr sports. Other considerations also would be importanty in any decision to including proximity to existingteamzs (a possible problem for Orlando), uniquer local factors (such as the prominence of gambling in Las and the availability of stadiums or arenas.

Stocks mostly off after Fed cuts growth outlook - MarketWatch

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TIME	Stocks mostly off after Fed cuts growth outlook MarketWatch NEW YORK (MarketWatch) â€" U.S. stocks ended mostly lower Wednesday after the Federal Reserve cut its growth forecasts and Chairman Ben Bernanke said ... Dollar Mostly Gains After Fed Move W »

Ancient warming turned Antarctica green - UPI.com

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UPI.com

Ancient warming turned Antarctica green UPI.com Ancient global warming  »

Three Kansas City-area entrepreneurs win Ernst & Young awards - Kansas City Business Journal:

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• Master category: James Ferrell, chairman and CEO, Overland Park-based (NYSE: • Technology category: August Grasis III, founder and Kansas City-based • Private equity/venturde capital backed category: Dr. Nicholas Franano, chief scientificd officer, and William Whitaker, vice president and general Kansas City-based Regional award winnersa are eligible for consideratioh for the Ernst Young LLP Entrepreneur of the Year 2009national awards, the company said in a Thursdayu release. National award winnera will be announced at an annual awardsgala Nov. 14 in Palm Calif.
Ernst & Young’s Entrepreneur of the Year awardx program celebrates its 23rd anniversary this The program has expanded to recognize business leaderxs in more than 135 cities in 50 The company said it gives the awards to entrepreneurz who demonstrate extraordinary successin innovation, financial performancre and personal commitment to their businesses and

Lessons from the ancient Maya on green vs. greed - Asheville Citizen-Times

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Lessons from the ancient Maya on green vs. greed Asheville Citizen-Times You've probably heard that the world as we know it is about to end in December, at least according to the wild prophecies some are reading into the ancient ... and more »

FDA questions General Mills' Cheerios marketing - Wichita Business Journal:

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The FDA told General Mills to stoppromotinh Cheerios, the country’s best-selling cereal, as a productt that can lower cholesterol reduce heart disease and reduce the risk of The agency said that claiminbg the cereal can lower cholesterol levelxs by 4 percent in six weeks amountas to marketing it as a drug and violatew the federal Food, Drug and Cosmeti Act. A local brancgh of the FDA gave theGolden Valley-basex food provider 15 days to explain how it will correctt its statements on Cheerios. In a prepared statement, Generalk Mills (NYSE: GIS) said the complaint doesn’t questionh whether the cereal actuallhy lowers cholesterol levels and said the dispute is over not science.
“The scientificc body of evidence supporting the heart health claim was the basisfor FDA’sd approval of the heart healtuh claim, and the clinical stud y supporting Cheerios’ cholesterol-lowering benefity is very strong,” the statement “We look forward to discussin g this with FDA and to reaching a Cheerios boxes say that two, one-and-a-half-cup servings of the cereakl every day have been clinically proven to lowerd cholesterol.
The message has been on the box for more thantwo

Public Companies: Is the belt tightening on exec pay? - The Business Review (Albany):

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Instead, the Glenville-based parent of Trustco Bank more than double d the salaries of CEO Robert McCormick and otherftop officers. McCormick, who had a salary of $400,000 in 2008, now will earn a base of In a proxy statement filed withthe , TrustCko said bonuses had been based on return on An ROE of under 13 percentt meant no payouts. The bank now has decidefd that this wastoo restrictive, givenj the pressure on banks to shore up their It therefore eliminated the bonus plan.
“Thisd decision reflected the [board’s] view that it was appropriatw in this time of economic uncertaintyt forthe executives’ cash compensatiobn to be less dependent on the achievement of performancer standards,” TrustCo’s proxy states. Bank officials declinesd further comment. Economic turbulence, along with shifting popular andpoliticalk sentiment, have public companies all over the country rethinkinv their compensation policies. Bonuses have been at the cented ofthe storm, especially after the public outrage that followed the payment of $165 million to executives at after the insurance giant was bailef out by taxpayers.
But all forms of compensationn are getting acloser “It’s obviously a very hot topic—oned might even say contentious,” said Paul DeNicola, associate director of the Governancse Center of The Conference Board, a nonprofit economic researcgh organization in New York “The sentiment has been brewing, but the statre of the economy exacerbatedx it.” There are four main components of executivre pay: salaries, benefits, bonuses and stockj options. For many performance-based pay makes up more than two-thirds of total The question at the heart of the debate is, did the performance—at a time of sinking corporated profits and stock prices—earn the pay?
Accordinfg to a survey by , a California-basedx compensation research firm, median pay for the CEO of a U.S. S&oP 500 company fell 6.8 percent in but still totaled $8.4 million. The media salary rose 6 to $1.06 million, while the median bonuse fell 21 percent, to $1.5 million. “It’s a complex said Janet Marler, associate professor in the Schoop of Business at thestate . “There are peoplr who feel executive payis well-designed and and is the reason U.S.
companies have done so “Others say CEOs are overpaid and that thei r pay has increased more thantheir performance, and that we are now seeiny the results—they are doinfg well and we’re left holdinb the bag,” she added. “There is probably truth in both The Conference Board has formed a task forcw onexecutive pay. Topics of discussionh will include the link between payand performance, ways to improvee public disclosure and the “say-on-pay” movement to give shareholders a voice in executive compensation.
“What I’m hearing from the investment community is that the most productiv e useof say-on-pay would be a referendum on the entire pay philosophy,” DeNicola said. What companies must do, Marler said, is try to “navigates between the two and fashion pay packages that attract and retain skilled executives without angeringthe public. She said few peopld object to performance-based pay—as long as it is set up “I think bonuses are a good she said. “The question is, what performance measures were used? Were they rewarding the right thing?
” , a Menands-basec maker of engineered fabricsand high-performance doors, lost $76 million in after 2007 income of $18 million. And yet, CEO Josep Morone received a bonusof

Chrysler-Fiat deal crosses finish line - Triangle Business Journal:

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The company is now knowb as and remains based inAuburn Mich. The Supreme Court, which had temporarilt held up the deal on Monday whilee it considered appeals by three Indiana state pensiob funds and several consumer said in an order that the groupw had not proven that the courft neededto intervene. Chrysler and Fiat reported Wednesdayu they concluded the deal duringthe morning. The plan to salvagr Chrysler will remake the companyg into one owned 55 percent by a unionpension trust, 20 percent owned by Fiat a share that could grow to 35 percent – and the rest owned by the governments of the Uniteed States and Canada.
Fiat cannot obtain a majority stakwe in Chrysler until all taxpayer fundsare "This is a very significant day, not only for Chryslet and its dedicated employees, who have persevered through a great deal of uncertainty during the past year, but for the global automotive industry as a whole," said Sergio Marchionne, who was namerd CEO of Chrysler Group, in a statement. "From the very we have been adamanyt that this alliance must be a constructivre and important step towardzs solving the problems impacting our We now look forward to establishing a new paradigm for how automotivd companies can operate profitablygoing forward.
" The new Chrysler will be managed by a nine-member board of directors, consisting of three directors to be appointef by Fiat, four directors to be appointesd by the U.S. government, one director to be appointed by the Canadian government and one directorf to be appointed by the United Auto Retiree MedicalBenefits Trust. The boarf is expected to name C. Robert Kiddet as chairman. On Tuesday, a federal bankruptcy judges in New York refused toblocmk Chrysler's effort to pull the franchises of 789

HART unveilsfirst rail column in East Kapolei - Honolulu Star-Advertiser

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HART unveilsfirst rail column in East Kapolei Honolulu Star-Advertiser By Star-Advertiser staff. The 23-foot column, off Old Farrington Highway in East Kapolei, is part of the first phase of construction for the multibillion-dollar project. Three hundred columns will be used to link East Kapolei to Pearl City. City offers first look at rail column KHON2 Roughly 700 columns are plan ned to go up along the 20-mile route KITV Honolulu  »

American Bio Medica secures $1.5M credit line - Kansas City Business Journal:

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The 3-year agreement with New York City-based provides America Bio Medica (Nasdaq: ABMC) with a $1.5 million revolvin line of credit. This line replacex one of the Kinderhook, N.Y. drug-tesg kit manufacturer’s previous credit facilitiez with . That line was for up to About $650,000 of the proceedxs from the new line have been used to repagFirst Niagara, which is basedr in Lockport, N.Y. The rest will be used to provides American Bio Medica with increased liquiditu for general corporate includingworking capital.
“Given the curreng status of thefinanciall markets, we are pleased with the completion of this and we appreciate the support provided by Rosenthal and Rosenthal, enabling us to increaser the size of our line of credit said Stan Cipkowski, CEO of American Bio “The additional borrowing capacity will providw the company with access to capital resourcess enabling us to weather these difficult economic times, as well as provid resources for our anticipated growth in the eventual He said the company now will focus on obtainingb new loans to replace its currentg term note and real estate mortgagwe with First Niagara. Those credits totao about $1 million.

Peco hires business development chief - The Business Review (Albany):

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The Galion-based communications power systemsx maker on Monday said it hired Al Cioffi as vice president of business He is in charge of developing new marketzs and striking partnershipsfor Peco. Cioffi arrivese at the companyfrom Richardson-based , where he was vice president of businesa development and product management. The company was formed last yearwhen Norway’sz bought Richardson’s Valere Powed for $130 million. Cioffo earlier served in an executive roleat Dallas-basedx and was a manager and designere for . He received a bachelor’ degree in electrical engineering from anda master’a in electrical engineering from the Polytechnic Institute of .
At Cioffi arrives weeks after the companyy said its board has begunconsidering “strategic alternatives” for the including an acquisition, merger or sale. Peco which employs about 180 lost $9.2 million on $26.7 milliojn in revenue last year.

Honda sales plunge 41% in May - Memphis Business Journal:

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’s American sales arm, , reported on Tuesdayg that the automakersold 98,344 vehiclees nationwide in May. A year ago, demans for fuel-efficient vehicles had sent Honda to a recorsd month of salesat 167,9987 vehicles. That represents a drop of 41 percentr from ayear ago, when prices at the pump were higher and the automobilee industry hadn’t yet hit crisis mode. Columbus Busineses First reports monthly sales unadjuste d for the differences in the number of selling days yearto year. Honda’s salees in May, taking into accountt one fewer selling day last fell39 percent.
Leading the decline in monthly sales for May wasthe company’ds flagship division, which saw a 42 percent drop in salea at 88,875 vehicles. Its luxurg Acura division saw sales fall 36 percentto 9,46i vehicles. Honda sales in the first five monthas of the year fell 34 percentto 430,358 vehicles, comparedd with 655,819 a year ago. That accounts for a 34 percent drop in Honda salesat 387,556 vehicles and a 35 percent decline in Acura sales at 42,802.
Marysville-based employa more than 12,000 workers at assembly and engine plants in and arounxCentral Ohio, where they produc e Honda Accords, Civics, CR-Vs, Elements and Acura TLs and

FHWA fears harming partnerships, GAO report says - The Trucker

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FHWA fears harming partnerships, GAO report says The Trucker “Based on GAO's review, there may be areas where national interests are less evident and where opportunities exist to narrow FHWA's responsibilities,” the report said. “Also, DOT should address the risks posed by its partnership approach.

40 Under Forty: Shawn Allan - New Mexico Business Weekly:

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While he focuses nowadays on ceramics andmaterialas technology, in high school Allan thought of majoring in Russian studies and linguistics, or polymer science, or ceramic engineering—“not really knowing what the latter two were all about.” It was his impressionx of a senior-year campus tour of , the Finger Lakes-areaq school so famous for its ceramics that led him to choose his curren field. At Alfred, Allan met an importantt mentor, Dr. Al Meier, who encouraged him to continuse withmaterials science. Meier recommended him for an internshiwith , a well-known research centedr in California. Allan also went to for a master’x degree.
Academics and career were not his only interestsin however; Allan also pursued social “I am quite proud of my work durinf college that directly resulted in a constitutional broadening of my international fraternity’sa non-discrimination policy,” Allan says. His written argumentse to the fraternity were publishee ina book, “Brotherhood.” At Ceralink, Allan has helpef write funding proposals for project such as energy-efficient manufacturing of laminated glass. He has been with the companty forfour years. “I enjoy the flexibilityt of my job, both in what I do and how I Allan says, “and also the flexibilitt to jugglepersonal life.
” Originally from Niagara Falls, Allan lives with his partner and cat in He enjoys snowboarding, cross-country skiing, running, hiking and backpacking, the Troy Farmer’s various Asian cuisines and literature. he has been reading “Ulysses” by Jame s Joyce and “Crime and Punishment” by Allan has been taking Spanish at Troy High Schookl and volunteers with Capital DistrictrCommunity Gardens. He also plays various instruments, includinf bagpipes, flute and saxophone. What does he think the region needs most?
A light-rail public transit

K&L Gates opens Dubai office - Pittsburgh Business Times:

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Dubai is the firm’s 33rd office and its firsg in theMiddle East. K&L Gated Chairman and Global Managing Partnerr Peter Kalis said the officewas “in the workx for about a year” and that the firm’ws entry was “well-timed compared with a year ago because the costs are reduced and theree is much more legal talent at more reasonabld compensation levels available on the market.” K&L Gates expects to grow the Dubai office principally through hires in that region. “I could see additional officee in theMiddle East,” said who first visited Dubai six monthz ago in preparing the firm’z entry there.
“Because of the concentration of financial and professional services in theDubai area, it’sw a very attractive and efficient point of entryt into the Gulf region. But certainly it’s not the only marketg for legal servicesthat matters. A logicak next step would be Abu Dhabi, but there is nothing scheduled for thatto K&L Gates is also “always” open to continuedf expansion opportunities internationally and in the continental United Kalis said, but did not identifg specific cities or countries. Neal one of the firm’s senior dispute resolutionb partners, is relocating from the Pittsburgh office to servdas co-founder of the Dubai office.
Joining Brendel is Paul de who most recently workedwith Ashurst, establishinb and managing that firm’s Dubai officd and helping to open a second officwe in the United Arab Emirates. He is a corporater and projects lawyer with more than 20 years experience. Associate Richard Dollimore also is joiningh theDubai office. He most recentlh worked in the K&L Gates office in London.